Our Research

Bio-engineering the human BBB

Traditional culture systems fail to represent the complexity of our physiology. The solution to some of these problems lies in microfluidic devices, also known as organs-on-chip or microphysiological devices that provide 3D multicellular architectures and can mimic tissue-tissue inter­faces, physicochemical microenvironments and vascular perfusion of the body, giving levels of tissue and organ functionality not attainable with conventional 2D or 3D culture systems. In collaboration with our commercial partners we bioengineered a platform of the human BBB, specifically designed for predictive personalized medicine, which we can now use to study the role of the BBB in neurological diseases.

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Post Mortem Human Brain

Immunohistochemical analysis of the human cerebellum reveals that MCT8 (green) is expressed in GLUT1 (red)-expressing blood vessels